New insights in sublingual immunotherapy

Sublingual immunotherapy (SLIT) is accepted in the official documents and is currently used in many European countries. In recent years, new clinical data on efficacy and safety have been published, including meta-analyses in adults and children and surveys of safety in children younger than age 5 y...

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Bibliographic Details
Published in:Current allergy and asthma reports 2006-09, Vol.6 (5), p.407-412
Main Authors: Passalacqua, Giovanni, Guerra, Laura, Compalati, Enrico, Fumagalli, Federica, Cirillo, Arianna, Canonica, Giorgio Walter
Format: Article
Language:English
Subjects:
Administration, Sublingual
Allergens - administration & dosage
Allergens - adverse effects
Asthma
Clinical Trials as Topic
Desensitization, Immunologic - adverse effects
Drug therapy
Humans
Respiratory Hypersensitivity - immunology
Respiratory Hypersensitivity - prevention & control
Respiratory Hypersensitivity - therapy
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Summary:Sublingual immunotherapy (SLIT) is accepted in the official documents and is currently used in many European countries. In recent years, new clinical data on efficacy and safety have been published, including meta-analyses in adults and children and surveys of safety in children younger than age 5 years. Moreover, it has been shown that, similar to the injection route, SLIT can prevent the onset of new sensitizations and the onset of asthma. Additionally, the mechanisms of action are beginning to be systematically studied. Some points need further investigation, such as the effect in asthma, the mechanisms of action, and the optimal dose to be administered.
ISSN:1529-7322
1534-6315
DOI:10.1007/s11882-996-0014-7