Early steps in neural crest specification

The neural crest is a multipotent cell population that arise at the border of the neural plate and non-neural ectoderm. Studies conducted in a number of model organisms including chickens, frogs, zebrafish and mice have been instrumental in elucidating this molecular mechanisms underlying neural cre...

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Bibliographic Details
Published in:Seminars in cell & developmental biology 2005-12, Vol.16 (6), p.642-646
Main Authors: Barembaum, Meyer, Bronner-Fraser, Marianne
Format: Article
Language:English
Subjects:
Animals
Anura
BMP
Chick Embryo
Danio rerio
Embryonic Induction
FGF
Mice
Mollusca
Neural crest
Neural Crest - cytology
Neural Crest - embryology
Neural Crest - metabolism
Signal Transduction
Slug
SoxE
Transcription Factors - genetics
Wnt
Xenopus
Zebrafish - embryology
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Summary:The neural crest is a multipotent cell population that arise at the border of the neural plate and non-neural ectoderm. Studies conducted in a number of model organisms including chickens, frogs, zebrafish and mice have been instrumental in elucidating this molecular mechanisms underlying neural crest formation. Signaling molecules of the Wnt, BMP, and FGF families and their downstream effectors have been shown to mediate neural crest induction. Transcription factors including members of the Snail and SoxE gene families as well as FoxD3, c-Myc and others have been implicated in specification of the neural crest. These studies represent an important step in understanding the regulatory interactions involved in generating this complex and interesting cell type.
ISSN:1084-9521
1096-3634
DOI:10.1016/j.semcdb.2005.06.006