Time trends of ischemic stroke incidence and mortality in patients diagnosed with first atrial fibrillation in 1980 to 2000 : Report of a community-based study

With the changes in management of atrial fibrillation (AF) over time, it is possible that the time trends of post-AF stroke incidence and mortality have changed. We sought to determine whether the incidence and survival of ischemic stroke after AF diagnosis have improved. We identified the Olmsted C...

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Bibliographic Details
Published in:Stroke (1970) 2005-11, Vol.36 (11), p.2362-2366
Main Authors: MIYASAKA, Yoko, BARNES, Marion E, GERSH, Bernard J, CHA, Stephen S, SEWARD, James B, BAILEY, Kent R, IWASAKA, Toshiji, TSANG, Teresa S. M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Aspirin - pharmacology
Aspirin - therapeutic use
Atrial Fibrillation - diagnosis
Atrial Fibrillation - epidemiology
Atrial Fibrillation - mortality
Biological and medical sciences
Blood Pressure
Blood. Blood coagulation. Reticuloendothelial system
Cardiac dysrhythmias
Cardiology. Vascular system
Female
Fibrinolytic Agents - pharmacology
Heart
Humans
Incidence
Ischemia - diagnosis
Ischemia - epidemiology
Ischemia - mortality
Male
Medical Records
Medical sciences
Middle Aged
Multivariate Analysis
Neurology
Pharmacology. Drug treatments
Proportional Hazards Models
Regression Analysis
Risk
Sex Factors
Stroke - diagnosis
Stroke - epidemiology
Stroke - mortality
Time Factors
Treatment Outcome
Vascular diseases and vascular malformations of the nervous system
Warfarin - pharmacology
Warfarin - therapeutic use
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Summary:With the changes in management of atrial fibrillation (AF) over time, it is possible that the time trends of post-AF stroke incidence and mortality have changed. We sought to determine whether the incidence and survival of ischemic stroke after AF diagnosis have improved. We identified the Olmsted County, Minn, residents who developed first AF from 1980 to 2000 and followed them in medical records to 2004. The outcomes were first ischemic stroke and death. Of the 4117 subjects diagnosed with first AF and without previous stroke, 446 (11%) sustained a first ischemic stroke during a mean follow-up time of 5.5+/-5.0 years. The age- and sex-adjusted incidence of stroke decreased, on average, by 3.4% per year (P=0.0001), concurrent with an increase in warfarin and aspirin use (both P
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.0000185927.63746.23