Avinosol, A Meroterpenoid-Nucleoside Conjugate with Antiinvasion Activity Isolated from the Marine Sponge Dysidea sp

The new meroterpenoids avinosol (1), 3‘-aminoavarone (2), and 3‘-phenethylaminoavarone (3) have been isolated from the marine sponge Dysidea sp. collected in Papua New Guinea, and their structures were elucidated by analysis of spectroscopic data. Avinosol (1), which is apparently the first example...

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Bibliographic Details
Published in:Organic letters 2006-08, Vol.8 (17), p.3749-3752
Main Authors: Diaz-Marrero, Ana R, Austin, Pamela, Van Soest, Rob, Matainaho, Teatulohi, Roskelley, Calvin D, Roberge, Michel, Andersen, Raymond J
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Drug Screening Assays, Antitumor
Dysidea - chemistry
Female
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Papua New Guinea
Terpenes - chemistry
Terpenes - isolation & purification
Terpenes - pharmacology
Tumor Cells, Cultured
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Summary:The new meroterpenoids avinosol (1), 3‘-aminoavarone (2), and 3‘-phenethylaminoavarone (3) have been isolated from the marine sponge Dysidea sp. collected in Papua New Guinea, and their structures were elucidated by analysis of spectroscopic data. Avinosol (1), which is apparently the first example of a naturally occurring meroterpenoid-nucleoside conjugate, showed antiinvasion activity in a cell-based assay.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol061333p