Purkinje Cell Apoptosis in Arabian Horses with Cerebellar Abiotrophy

Summary Purkinje cerebellar cells were studied in three Arabian horses aged between 6 and 8 months with clinical disorders in their movements, tremors and ataxia; the occurrence of apoptosis in this cell population was investigated by the (terminal deoxynucleotidyl transferase biotin‐dUTP nick‐end l...

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Bibliographic Details
Published in:Journal of veterinary medicine. Series A 2006-08, Vol.53 (6), p.286-287
Main Authors: Blanco, A., Moyano, R., Vivo, J., Flores-Acuña, R., Molina, A., Blanco, C., Monterde, J. G.
Format: Article
Language:English
Subjects:
Animals
Apoptosis - physiology
Cell Nucleus - pathology
Cerebellar Ataxia
Cerebellar Cortex - cytology
Cerebellar Cortex - pathology
Cerebellar Cortex - ultrastructure
Horse Diseases - pathology
Horses
In Situ Nick-End Labeling - methods
In Situ Nick-End Labeling - veterinary
Purkinje Cells - pathology
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Summary:Summary Purkinje cerebellar cells were studied in three Arabian horses aged between 6 and 8 months with clinical disorders in their movements, tremors and ataxia; the occurrence of apoptosis in this cell population was investigated by the (terminal deoxynucleotidyl transferase biotin‐dUTP nick‐end labelling (TUNEL) method. Both optical and electron microscopical images showed a scant number of Purkinje cells, most of them with morphological features of apoptosis such as condensation of the nucleus and cytoplasm as well as segregation and fragmentation of the nucleus into apoptotic bodies. The TUNEL technique revealed a substantial number (65%) of positive immunoreactive Purkinje cells.
ISSN:0931-184X
1439-0442
DOI:10.1111/j.1439-0442.2006.00836.x