Role of heat shock proteins (molecular chaperones) in intestinal mucosal protection

Most studies into the pathogenesis of inflammatory bowel diseases (IBD) have primarily focused on the cytotoxic agents and processes involved in producing mucosal injury, including the immune system. However, less consideration has been given to the inherent mechanisms of cytoprotection and cellular...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2006-09, Vol.348 (1), p.1-5
Main Authors: Otaka, Michiro, Odashima, Masaru, Watanabe, Sumio
Format: Article
Language:English
Subjects:
Animals
Colon
Crohn’s disease
Cytoprotection
Heat shock protein
Heat-Shock Proteins - physiology
Heat-Shock Response - physiology
HSP
Humans
IBD
Inflammatory Bowel Diseases - etiology
Inflammatory Bowel Diseases - metabolism
Inflammatory Bowel Diseases - prevention & control
Intestinal Mucosa - pathology
Intestinal Mucosa - physiology
Intestine
Molecular chaperone
Molecular Chaperones - physiology
Stress
Ulcerative colitis
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Summary:Most studies into the pathogenesis of inflammatory bowel diseases (IBD) have primarily focused on the cytotoxic agents and processes involved in producing mucosal injury, including the immune system. However, less consideration has been given to the inherent mechanisms of cytoprotection and cellular repair in the intestinal mucosa. This review will focus on intestinal mucosal protection against cytotoxic agents and cellular stress mainly from the viewpoint of expression and function of heat shock proteins, in their role of “molecular chaperones,” as internal cytoprotectants. Elucidation of such stress-responses in the intestinal mucosa may provide a better understanding of the mechanisms of cytoprotection and cellular repair, and present new strategies for IBD therapy.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2006.07.028