Integrin-mediated activation of latent transforming growth factor beta

Members of the integrin family recognize a variety of spatially-restricted extracellular ligands. Classically, ligation of integrins activates cytoplasmic signals in the integrin-expressing cell and contributes to cell adhesion, migration, proliferation and survival. At least two members of this fam...

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Bibliographic Details
Published in:Cancer and metastasis reviews 2005-09, Vol.24 (3), p.395-402
Main Author: Sheppard, Dean
Format: Article
Language:English
Subjects:
Animals
Antigens, Neoplasm - metabolism
Cell Adhesion
Cell Line, Tumor
Cell Movement
Cell Proliferation
Cell Survival
Cytoplasm - metabolism
Epithelial Cells - metabolism
Gene Expression Regulation, Neoplastic
Humans
Integrins - metabolism
Models, Biological
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasms - pathology
Transforming Growth Factor beta - metabolism
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Summary:Members of the integrin family recognize a variety of spatially-restricted extracellular ligands. Classically, ligation of integrins activates cytoplasmic signals in the integrin-expressing cell and contributes to cell adhesion, migration, proliferation and survival. At least two members of this family, alphavbeta6 and alphavbeta8 perform an additional function, activation of latent complexes of transforming growth factor beta. In effect, this process allows integrins on one cell to activate signals on adjacent (in the case of alphavbeta6) or nearby cells (in the case of alphavbeta8). Integrin-mediated TGFbeta activation has been shown to play important roles in modulating tissue fibrosis, acute lung injury and pulmonary emphysema. Given the important roles that TGFbeta plays in modulating epithelial cell growth, epithelial-to-mesenchymal transformation and tumor invasion and metastasis, integrin-mediated TGFbeta activation is likely to play important roles in tumor growth and metastasis.
ISSN:0167-7659
1573-7233
DOI:10.1007/s10555-005-5131-6