In vitro effects of crude extracts of Parkia biglobosa (Mimosaceae), Stereospermum kunthianum (Bignoniaceae) and Biophytum petersianum (Oxalidaceae) on corticosteroid secretion in rat

Previous studies conducted in guinea pig, rat and rabbit have revealed that crude extracts from Parkia biglobosa, Stereospermum kunthianum and Biophytum petersianum exert hypotensive and/or hypoglycemic activities. Since corticosteroids are involved in the control of arterial blood pressure and glyc...

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Bibliographic Details
Published in:The Journal of steroid biochemistry and molecular biology 2006-08, Vol.100 (4), p.202-208
Main Authors: Kodjo, K.M., Contesse, V., Do Rego, J.L., Aklikokou, K., Titrikou, S., Gbeassor, M., Vaudry, H.
Format: Article
Language:English
Subjects:
Acacia - chemistry
Adrenal Cortex Hormones - secretion
Adrenal gland
Adrenal Glands - drug effects
Animals
Bignoniaceae - chemistry
Biological and medical sciences
Corticosteroid secretion
Dose-Response Relationship, Drug
Fundamental and applied biological sciences. Psychology
Guinea Pigs
Magnoliopsida - chemistry
Medicinal plants
Plant Extracts - pharmacology
Plants, Medicinal - chemistry
Rabbits
Rats
Rats, Wistar
Vertebrates: endocrinology
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Summary:Previous studies conducted in guinea pig, rat and rabbit have revealed that crude extracts from Parkia biglobosa, Stereospermum kunthianum and Biophytum petersianum exert hypotensive and/or hypoglycemic activities. Since corticosteroids are involved in the control of arterial blood pressure and glycemia, we have investigated the possible effects of these plant extracts on rat adrenal tissue in vitro. Short-term administration of crude semi-ethanolic extracts of P. biglobosa and S. kunthianum to perifused rat adrenal tissue did not induce any significant changes in corticosteroid output. Conversely, the B. petersianum extract caused a dose-dependent increase in corticosterone and aldosterone secretion. Repeated infusions or prolonged administration of B. petersianum extract did not produce any apparent attenuation of the steroid response. Altogether, these data indicate that a semi-ethanolic extract of B. petersianum dose-dependently stimulates corticosterone and aldosterone secretion in rat without any desensitization phenomenon.
ISSN:0960-0760
1879-1220
DOI:10.1016/j.jsbmb.2006.04.010