Regeneration of human infarcted heart muscle by intracoronary autologous bone marrow cell transplantation in chronic coronary artery disease: the IACT Study

Stem cell therapy may be useful in chronic myocardial infarction (MI); this is conceivable, but not yet demonstrated in humans. After acute MI, bone marrow-derived cells improve cardiac function. We treated 18 consecutive patients with chronic MI (5 months to 8.5 years old) by the intracoronary tran...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2005-11, Vol.46 (9), p.1651-1658
Main Authors: Strauer, Bodo E, Brehm, Michael, Zeus, Tobias, Bartsch, Thomas, Schannwell, Christina, Antke, Christine, Sorg, Rüdiger V, Kögler, Gesine, Wernet, Peter, Müller, Hans-Wilhelm, Köstering, Matthias
Format: Article
Language:English
Subjects:
Adult
Anaerobic threshold
Angioplasty
Bone marrow
Bone Marrow Transplantation - methods
Cardiology
Cardiovascular disease
Catheters
Chronic Disease
Coronary Artery Disease - surgery
Coronary Vessels
Drug therapy
Ejection fraction
Enzymes
Exercise
Heart
Heart - physiology
Humans
Male
Medical imaging
Middle Aged
Myocardial Infarction - surgery
Myocardium
Regeneration
Stem cell transplantation
Tomography
Workloads
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Summary:Stem cell therapy may be useful in chronic myocardial infarction (MI); this is conceivable, but not yet demonstrated in humans. After acute MI, bone marrow-derived cells improve cardiac function. We treated 18 consecutive patients with chronic MI (5 months to 8.5 years old) by the intracoronary transplantation of autologous bone marrow mononuclear cells and compared them with a representative control group without cell therapy. After three months, in the transplantation group, infarct size was reduced by 30% and global left ventricular ejection fraction (+15%) and infarction wall movement velocity (+57%) increased significantly, whereas in the control group no significant changes were observed in infarct size, left ventricular ejection fraction, or wall movement velocity of infarcted area. Percutaneous transluminal coronary angioplasty alone had no effect on left ventricular function. After bone marrow cell transplantation, there was an improvement of maximum oxygen uptake (VO2max, +11%) and of regional 18F-fluor-desoxy-glucose uptake into infarct tissue (+15%). These results demonstrate that functional and metabolic regeneration of infarcted and chronically avital tissue can be realized in humans by bone marrow mononuclear cell transplantation.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2005.01.069