Polymorphisms of the BRCA2 and RAD51 genes in breast cancer

We performed a case-control study (150 cases and 150 controls) to test the association between three polymorphisms in BRCA2 and RAD51 genes and breast cancer risk. Genotypes were determined in DNA from blood cells by PCR-RFLP. Cancer occurrence was strongly associated with the BRCA2 Met/1915Thr homo...

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Bibliographic Details
Published in:Breast cancer research and treatment 2005-11, Vol.94 (2), p.105-109
Main Authors: SLIWINSKI, Tomasz, KRUPA, Renata, MAJSTEREK, Ireneusz, RYKALA, Jan, KOLACINSKA, Agnieszka, MORAWIEC, Zbigniew, DRZEWOSKI, Jozef, ZADROZNY, Marek, BLASIAK, Janusz
Format: Article
Language:English
Subjects:
Biological and medical sciences
BRCA2 Protein - genetics
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Cancer research
Cancer therapies
Carcinoma, Intraductal, Noninfiltrating - genetics
Carcinoma, Intraductal, Noninfiltrating - pathology
Case-Control Studies
DNA - analysis
European Continental Ancestry Group - genetics
Female
Genes
Genotype
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical sciences
Middle Aged
Poland
Polymerase Chain Reaction
Polymorphism
Polymorphism, Genetic
Rad51 Recombinase - genetics
Risk assessment
Tumors
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Summary:We performed a case-control study (150 cases and 150 controls) to test the association between three polymorphisms in BRCA2 and RAD51 genes and breast cancer risk. Genotypes were determined in DNA from blood cells by PCR-RFLP. Cancer occurrence was strongly associated with the BRCA2 Met/1915Thr homozygous polymorphic variants, whereas heterozygous variant was associated with significant reduction in breast cancer risk. Gene-gene interaction between the BRCA2-Met1915Thr Thr/Thr and BRCA2-Met784Val Met/Met homozygous variants increased the risk. Therefore, the Met1915Thr polymorphism in the BRCA2 gene may be considered as an independent marker of breast cancer.
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-005-0672-5