Mapping of a novel susceptibility gene for rheumatoid arthritis in the telomeric MHC region

Rheumatoid arthritis (RA) is a complex heterogeneous disease with an estimated genetic contribution to of 30–50%. Approximately one third arises from the major histocompatibility complex (MHC) at 6p21.3. The contribution of specific DRB1 alleles encoding the shared epitope has been well described, h...

Full description

Saved in:
Bibliographic Details
Published in:Cytokine (Philadelphia, Pa.) Pa.), 2005-10, Vol.32 (2), p.71-75
Main Authors: Kilding, Rachael, Wilson, Anthony G.
Format: Article
Language:English
Subjects:
Arthritis, Rheumatoid - genetics
Chromosomes, Human, Pair 6
Epitopes
Genetic Predisposition to Disease
Genetics
HLA-DR Antigens - genetics
HLA-DRB1 Chains
Humans
Linkage Disequilibrium
Major Histocompatibility Complex
MHC
Polymorphism
Rheumatoid arthritis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Rheumatoid arthritis (RA) is a complex heterogeneous disease with an estimated genetic contribution to of 30–50%. Approximately one third arises from the major histocompatibility complex (MHC) at 6p21.3. The contribution of specific DRB1 alleles encoding the shared epitope has been well described, however, several recent studies have suggested that additional telomeric genetic influences may exist. This region is difficult to study as a result of the presence of strong linkage disequilibrium (LD) within the MHC and high gene density particularly in the central class III region. In this article we review the current data supporting the existence of a non-DRB1 susceptibility gene for rheumatoid arthritis, in particular within the class III region.
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2005.07.015