The CFTA Method: A Reliable Procedure for the Determination of the Absolute Configuration of Chiral Primary Amines by 1H NMR Spectroscopic Analysis

Surprisingly stable anti‐periplanar conformers of CFTA amides form the basis of a new and very reliable method for determining the absolute configuration of chiral primary amines by 1H NMR spectroscopy (see picture). CFTA=α‐cyano‐α‐fluoro‐p‐tolylacetic acid.

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2006-07, Vol.45 (28), p.4617-4619
Main Authors: Takeuchi, Yoshio, Segawa, Masaru, Fujisawa, Hidehito, Omata, Kenji, Lodwig, Siegfried N., Unkefer, Clifford J.
Format: Article
Language:English
Subjects:
Acetates - chemistry
Amines - chemistry
CFTA diastereomers
configuration determination
Magnetic Resonance Spectroscopy - methods
Molecular Structure
NMR spectroscopy
reactivity
Toluene - analogs & derivatives
Toluene - chemistry
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Description
Summary:Surprisingly stable anti‐periplanar conformers of CFTA amides form the basis of a new and very reliable method for determining the absolute configuration of chiral primary amines by 1H NMR spectroscopy (see picture). CFTA=α‐cyano‐α‐fluoro‐p‐tolylacetic acid.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200600157