PAMAM dendrimers and model membranes: Differential scanning calorimetry studies

Dendrimers attract much attention as potential drug and gene carriers for intracellular delivery. From this point of view, it is crucial to extend our knowledge about their interactions with membranes. The influence of polyamidoamine (PAMAM) dendrimers on the thermotropic behavior of DPPC multilamel...

Full description

Saved in:
Bibliographic Details
Published in:International journal of pharmaceutics 2005-11, Vol.305 (1), p.154-166
Main Authors: Klajnert, B., Epand, R.M.
Format: Article
Language:English
Subjects:
1,2-Dipalmitoylphosphatidylcholine - chemistry
Biocompatible Materials - chemistry
Biological and medical sciences
Calorimetry, Differential Scanning
Dendrimer
Dendrimers
Dimyristoylphosphatidylcholine - chemistry
DSC
General pharmacology
Hydrophobic and Hydrophilic Interactions
Liposome
Liposomes - chemistry
Medical sciences
Membrane
Membranes, Artificial
MLV
Molecular Structure
PAMAM
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polyamines - chemistry
SUV
Vesicle
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Dendrimers attract much attention as potential drug and gene carriers for intracellular delivery. From this point of view, it is crucial to extend our knowledge about their interactions with membranes. The influence of polyamidoamine (PAMAM) dendrimers on the thermotropic behavior of DPPC multilamellar vesicles and DMPC small unilamellar vesicles was examined by differential scanning calorimetry. We used three types of PAMAM dendrimers to determine how a dendrimer structure determines interactions with liposomes. We show that the strength of interactions depends on both the dendrimers’ structure and degree of hydrophobicity. A model for the interaction of each type of dendrimer with liposomes was proposed.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2005.08.015