Folding and Unfolding Kinetics of the i-Motif Structure Formed by the C-Rich Strand of Human Telomere DNA

Return to the fold. Nucleic acids with four tandem cytidine‐rich repeats can fold into a structure called the i‐motif at acidic pH. The folding‐ and unfolding‐rate constants of such a sequence in vertebrate telomere DNA were measured. Protons were found to promote i‐motif formation by increasing the...

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Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2005-11, Vol.6 (11), p.1957-1960
Main Authors: Zhao, Yong, Zeng, Zhi-xiong, Kan, Zhong-yuan, Hao, Yu-hua, Tan, Zheng
Format: Article
Language:English
Subjects:
Base Pairing
Biosensing Techniques
Cytidine - chemistry
DNA - chemistry
folding
Humans
Hydrogen Bonding
Hydrogen-Ion Concentration
i-motif
Kinetics
Nucleic Acid Conformation
nucleic acids
secondary structure
Telomere - chemistry
telomeres
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Summary:Return to the fold. Nucleic acids with four tandem cytidine‐rich repeats can fold into a structure called the i‐motif at acidic pH. The folding‐ and unfolding‐rate constants of such a sequence in vertebrate telomere DNA were measured. Protons were found to promote i‐motif formation by increasing the folding and decreasing the unfolding.
ISSN:1439-4227
1439-7633
1439-4227
DOI:10.1002/cbic.200500175