Folding and Unfolding Kinetics of the i-Motif Structure Formed by the C-Rich Strand of Human Telomere DNA

Return to the fold. Nucleic acids with four tandem cytidine‐rich repeats can fold into a structure called the i‐motif at acidic pH. The folding‐ and unfolding‐rate constants of such a sequence in vertebrate telomere DNA were measured. Protons were found to promote i‐motif formation by increasing the...

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Published in:Chembiochem : a European journal of chemical biology 2005-11, Vol.6 (11), p.1957-1960
Main Authors: Zhao, Yong, Zeng, Zhi-xiong, Kan, Zhong-yuan, Hao, Yu-hua, Tan, Zheng
Format: Article
Language:English
Subjects:
Base Pairing
Biosensing Techniques
Cytidine - chemistry
DNA - chemistry
folding
Humans
Hydrogen Bonding
Hydrogen-Ion Concentration
i-motif
Kinetics
Nucleic Acid Conformation
nucleic acids
secondary structure
Telomere - chemistry
telomeres
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cited_by cdi_FETCH-LOGICAL-c4365-39ee7bf2a0c95db76958ac585e5cf4669b3c23eb406fb2896d7f8102888b41613
cites cdi_FETCH-LOGICAL-c4365-39ee7bf2a0c95db76958ac585e5cf4669b3c23eb406fb2896d7f8102888b41613
container_end_page 1960
container_issue 11
container_start_page 1957
container_title Chembiochem : a European journal of chemical biology
container_volume 6
creator Zhao, Yong
Zeng, Zhi-xiong
Kan, Zhong-yuan
Hao, Yu-hua
Tan, Zheng
description Return to the fold. Nucleic acids with four tandem cytidine‐rich repeats can fold into a structure called the i‐motif at acidic pH. The folding‐ and unfolding‐rate constants of such a sequence in vertebrate telomere DNA were measured. Protons were found to promote i‐motif formation by increasing the folding and decreasing the unfolding.
doi_str_mv 10.1002/cbic.200500175
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source Wiley
subjects Base Pairing
Biosensing Techniques
Cytidine - chemistry
DNA - chemistry
folding
Humans
Hydrogen Bonding
Hydrogen-Ion Concentration
i-motif
Kinetics
Nucleic Acid Conformation
nucleic acids
secondary structure
Telomere - chemistry
telomeres
title Folding and Unfolding Kinetics of the i-Motif Structure Formed by the C-Rich Strand of Human Telomere DNA
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