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Cellular Immune Responses against Hepatitis C Virus
Cellular immune responses are typically important in recovery from acute infections, and studies of acute hepatitis C confirm that broadly directed CD4+ and CD8+ T cell responses are associated with spontaneous clearance of infection. However, a major unanswered question is what role the cellular im...
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| Published in: | Clinical infectious diseases 2005-07, Vol.41 (Supplement-1), p.S25-S31 |
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| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c426t-df92914b6ecccd89e66ff9be38d85a80b80122bd0c80be10458864e06291a7393 |
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| cites | cdi_FETCH-LOGICAL-c426t-df92914b6ecccd89e66ff9be38d85a80b80122bd0c80be10458864e06291a7393 |
| container_end_page | S31 |
| container_issue | Supplement-1 |
| container_start_page | S25 |
| container_title | Clinical infectious diseases |
| container_volume | 41 |
| creator | Koziel, Margaret James |
| description | Cellular immune responses are typically important in recovery from acute infections, and studies of acute hepatitis C confirm that broadly directed CD4+ and CD8+ T cell responses are associated with spontaneous clearance of infection. However, a major unanswered question is what role the cellular immune response plays in progression of liver disease during chronic infection. Classic models of hepatitis C suggest that cellular immune responses promote liver injury, either by causing direct cytolysis of infected cells or by promoting inflammation. However, clinical evidence suggests that persons with cellular immune dysfunction, such as that due to with human immunodeficiency virus (HIV) infection, have more-rapid disease progression. Recent data suggest that cellular immune responses do serve to limit the progression of liver disease, even if they are ineffective at clearance of virus. There is limited information on the effect of HIV coinfection on the cellular immune response to hepatitis C virus, but further study of this issue might shed light on the pathogenesis of liver disease in both immunocompromised and nonimmunocompromised hosts. |
| doi_str_mv | 10.1086/429492 |
| format | article |
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There is limited information on the effect of HIV coinfection on the cellular immune response to hepatitis C virus, but further study of this issue might shed light on the pathogenesis of liver disease in both immunocompromised and nonimmunocompromised hosts.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/429492</identifier><identifier>PMID: 16265610</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Animals ; Blood ; CD4-Positive T-Lymphocytes - immunology ; CD4-Positive T-Lymphocytes - virology ; CD8-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - virology ; Chronic hepatitis ; Cytokines ; Hepacivirus ; Hepacivirus - immunology ; Hepatitis ; Hepatitis C ; Hepatitis C - complications ; Hepatitis C - immunology ; Hepatitis C virus ; Hepatitis C, Chronic - immunology ; HIV ; HIV Infections - complications ; HIV Infections - immunology ; Human immunodeficiency virus ; Humans ; Immune system ; Immunity, Cellular - immunology ; Infections ; Killer Cells, Natural - immunology ; Liver ; Mice ; T lymphocytes ; Viruses</subject><ispartof>Clinical infectious diseases, 2005-07, Vol.41 (Supplement-1), p.S25-S31</ispartof><rights>Copyright 2005 The Infectious Diseases Society of America</rights><rights>Copyright University of Chicago, acting through its Press Jul 1, 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-df92914b6ecccd89e66ff9be38d85a80b80122bd0c80be10458864e06291a7393</citedby><cites>FETCH-LOGICAL-c426t-df92914b6ecccd89e66ff9be38d85a80b80122bd0c80be10458864e06291a7393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4463316$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4463316$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,58238,58471</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16265610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koziel, Margaret James</creatorcontrib><title>Cellular Immune Responses against Hepatitis C Virus</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><description>Cellular immune responses are typically important in recovery from acute infections, and studies of acute hepatitis C confirm that broadly directed CD4+ and CD8+ T cell responses are associated with spontaneous clearance of infection. 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There is limited information on the effect of HIV coinfection on the cellular immune response to hepatitis C virus, but further study of this issue might shed light on the pathogenesis of liver disease in both immunocompromised and nonimmunocompromised hosts.</description><subject>Animals</subject><subject>Blood</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD4-Positive T-Lymphocytes - virology</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes - virology</subject><subject>Chronic hepatitis</subject><subject>Cytokines</subject><subject>Hepacivirus</subject><subject>Hepacivirus - immunology</subject><subject>Hepatitis</subject><subject>Hepatitis C</subject><subject>Hepatitis C - complications</subject><subject>Hepatitis C - immunology</subject><subject>Hepatitis C virus</subject><subject>Hepatitis C, Chronic - immunology</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - 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| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 2005-07, Vol.41 (Supplement-1), p.S25-S31 |
| issn | 1058-4838 1537-6591 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68753394 |
| source | JSTOR Archival Journals and Primary Sources Collection; Oxford Journals Online |
| subjects | Animals Blood CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - virology Chronic hepatitis Cytokines Hepacivirus Hepacivirus - immunology Hepatitis Hepatitis C Hepatitis C - complications Hepatitis C - immunology Hepatitis C virus Hepatitis C, Chronic - immunology HIV HIV Infections - complications HIV Infections - immunology Human immunodeficiency virus Humans Immune system Immunity, Cellular - immunology Infections Killer Cells, Natural - immunology Liver Mice T lymphocytes Viruses |
| title | Cellular Immune Responses against Hepatitis C Virus |
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