Serum deoxyribonuclease I activity can be used as a sensitive marker for detection of transient myocardial ischaemia induced by percutaneous coronary intervention

• Published in: European heart journal 2005-11, Vol.26 (22), p.2375-2380
• Main Authors: Arakawa, Kenichiro, Kawai, Yasuyuki, Kumamoto, Teruhiko, Morikawa, Norihiro, Yoshida, Masahiro, Tada, Hiroshi, Kawaguchi, Ren, Taniguchi, Koichi, Miyamori, Isamu, Kominato, Yoshihiko, Kishi, Koichiro, Yasuda, Toshihiro
• Format: Article
• Language: English
• Subjects: Aged; Angioplasty; Angioplasty, Balloon, Coronary - adverse effects; Biological and medical sciences; Biomarkers - blood; Cardiology. Vascular system; Case-Control Studies; Coronary heart disease; Deoxyribonuclease I; Deoxyribonuclease I - blood; Female; Heart; Humans; Ischaemia; Male; Medical sciences; Myocardial Ischemia - blood; Myocardial Ischemia - diagnosis; Myocardial Ischemia - etiology; Myocarditis. Cardiomyopathies
• ISSN: 0195-668X; 1522-9645
• DOI: 10.1093/eurheartj/ehi228

Aims Cardiac markers such as troponin T (c-TnT) have proven unsuitable for the detection of early and transient myocardial ischaemia. We recently reported that abrupt elevation of serum deoxyribonuclease I (DNase I) activity in the early stage of acute myocardial infarction could be used as a diagnostic marker. To evaluate whether serum DNase I could be used as a marker of early myocardial ischaemia, we investigated alterations in its levels after transient ischaemia induced during percutaneous coronary intervention (PCI). Methods and results In 24 consecutive patients with stable angina undergoing elective PCI and 12 patients undergoing coronary angiography (CAG), serum samples were tested for DNase I, creatine kinase isoenzyme MB (CK-MB), and c-TnT before, soon after, and 3 and 12–24 h after completion of the procedures. Serum DNase I activity had risen significantly from baseline by 3 h after PCI in 21 of the 24 PCI patients. The mean per cent difference from baseline in serum DNase I activity 3 h after PCI was 35.9±37.5%. Even among the 16 PCI patients whose levels of CK-MB and c-TnT were within the normal range, 13 showed elevation of serum DNase I activity from baseline after PCI. In the CAG patient group, DNase I activity levels remained unchanged at all times after CAG. Conclusion Elevation of serum DNase I activity can be used as a sensitive marker for detection of transient myocardial ischaemia.