Microvessel density and vascular endothelial growth factor expression in sinus augmentation using Bio-Oss

• Published in: Oral diseases 2006-09, Vol.12 (5), p.469-475
• Main Authors: Degidi, M, Artese, L, Rubini, C, Perrotti, V, Iezzi, G, Piattelli, A
• Format: Article
• Language: English
• Subjects: Adult; Aged; Alveolar Process - blood supply; Alveolar Ridge Augmentation - methods; Animals; anorganic bovine bone; Bone Substitutes - therapeutic use; Bone Transplantation - methods; Cattle; Dentistry; Female; Humans; Male; Maxillary Sinus - blood supply; Maxillary Sinus - cytology; Maxillary Sinus - surgery; Microcirculation; microvessel density; Middle Aged; Minerals - therapeutic use; sinus augmentation procedures; vascular endothelial growth factor; Vascular Endothelial Growth Factor A - analysis; xenogenic bone
• ISSN: 1354-523X; 1601-0825
• DOI: 10.1111/j.1601-0825.2006.01222.x

Aim:  The aim of this study was to evaluate microvessel density (MVD) and vascular endothelial growth factor (VEGF) expression in sinus augmentation with Bio‐Oss®. Methods:  Twenty patients participated in this study. The sinuses were filled with 100% Bio‐Oss®. Implants were inserted after 3 months in group A, and 6 months in group B. A trephine was used to harvest bone cores. As control, the pre‐existing subantral bone was used. Results:  The mean MVD in control bone was 23.6 ± 1.8. In the sites augmented with Bio‐Oss®, at 3 months, the MVD was 23.3 ± 2.1, while in the sites retrieved at 6 months the MVD was 29.5 ± 2.4. The difference in MVD between the control bone and group A was not statistically significant. The difference between the control bone and group B was statistically significant (P