Chronic Inflammation and Breast Pathology: A Theoretical Model

Breast cell pathology results from biochemical and molecular changes that culminate in the cell’s loss of functional responsiveness. The epithelial cell compartment in the breast ductal system is the site of approximately 98% of malignant proliferations, and it is from within these cells that the fi...

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Bibliographic Details
Published in:Biological research for nursing 2005-10, Vol.7 (2), p.118-129
Main Authors: Lithgow, Diana, Covington, Chandice
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - metabolism
Breast Neoplasms - physiopathology
Cytokines - metabolism
Female
Humans
Inflammation - physiopathology
Mammary Glands, Human - pathology
Mammary Glands, Human - secretion
Models, Theoretical
Nursing
Oxidative Stress
Proteomics
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Summary:Breast cell pathology results from biochemical and molecular changes that culminate in the cell’s loss of functional responsiveness. The epithelial cell compartment in the breast ductal system is the site of approximately 98% of malignant proliferations, and it is from within these cells that the first biochemical signal of change may be expressed as an inflammatory response. Inflammation may be represented by biomarkers of early pathologic changes in breast cells and be associated with risk for the development of breast cancer. A theoretical model of the inflammatory process is proposed showing predictive linkages among stimuli in the breast microenvironment and the development of breast pathology, in particular, breast cancer. This model fuels intervention concepts that may prevent malignant breast health outcomes.
ISSN:1099-8004
1552-4175
DOI:10.1177/1099800405280823