Changes in activity of the hypothalamic neurons in response to physiological fluctuations of the homeostasis constants

In acute experiments on cats under the combined narcosis (ketamine + N2O) we have investigated impulse activity of the rostral hypothalamic neurons and analyzed its modifications due to visceral stimulation. As stimulation we used warmed up or cooled (on 7 degrees C) a paw of an animals, cooled a bo...

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Bibliographic Details
Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2006, Vol.52 (3), p.57-63
Main Author: Natrus, L V
Format: Article
Language:Ukrainian
Subjects:
Action Potentials - drug effects
Action Potentials - physiology
Animals
Cats
Evoked Potentials, Somatosensory - drug effects
Evoked Potentials, Somatosensory - physiology
Female
Glucose - pharmacology
Homeostasis - drug effects
Homeostasis - physiology
Hypothalamus - drug effects
Hypothalamus - physiology
Male
Microelectrodes
Neurons - drug effects
Neurons - physiology
Phenylephrine - pharmacology
Sodium Chloride - pharmacology
Temperature
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Summary:In acute experiments on cats under the combined narcosis (ketamine + N2O) we have investigated impulse activity of the rostral hypothalamic neurons and analyzed its modifications due to visceral stimulation. As stimulation we used warmed up or cooled (on 7 degrees C) a paw of an animals, cooled a body of an animal, we administered solutions into a carotid artery: 5 % of glucose, 0,2 % and 3 % NaCl, phenilephrine. Thus we modeled fluctuation of homeostasis's constants in physiological limits in an animal organism. It is shown that the greatest quantity of investigated neurons--more than 10 % authentically changes a pattern impulse activity when we entered solutions of 5 % of glucose and 0,2 % NaCl into a carotid artery of animals. In other cases the degree of transformation of a pattern was less (6-7 %) and approximately identical. When we entered of a microdose phenilephrine into the v. femoralis in order to modulate press effect we registered minimal quantity of neurons (1,4%). Studing of the parameters of the IA hypothalamic neurons during the homeostatic changes could be a basis for finding of transformation of the functional state of neurons which take part in the regulator mechanisms for maintaining of homeostasis.
ISSN:2522-9028