Regulation of cyclooxygenase catalysis by hydroperoxides

Activation of cyclooxygenase catalysis in prostaglandin H synthase-1 and -2 by peroxide-dependent formation of a tyrosyl radical is emerging as an important part of regulating cellular production of bioactive prostanoids. This review discusses the mechanism of tyrosyl radical formation and the influ...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2005-12, Vol.338 (1), p.25-33
Main Author: Kulmacz, Richard J.
Format: Article
Language:English
Subjects:
Animals
Cyclooxygenase activation
Humans
Hydrogen Peroxide - chemistry
Hydrogen Peroxide - metabolism
Peroxide
Prostaglandin H synthase
Prostaglandin-Endoperoxide Synthases - chemistry
Prostaglandin-Endoperoxide Synthases - metabolism
Tyrosyl radical
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Summary:Activation of cyclooxygenase catalysis in prostaglandin H synthase-1 and -2 by peroxide-dependent formation of a tyrosyl radical is emerging as an important part of regulating cellular production of bioactive prostanoids. This review discusses the mechanism of tyrosyl radical formation and the influence of peroxide, fatty acid, peroxidase cosubstrate, and protein structure on the activation process and cyclooxygenase catalysis.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2005.08.030