Female gout: clinical and laboratory features

OBJECTIVE: To evaluate and compare clinical and laboratory features of gout in men and women. METHODS: Twenty-seven women and 31 men with gout underwent clinical and laboratory evaluation and review of medical records. RESULTS: Disease onset in women was a mean of 7 years later than in men. There we...

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Bibliographic Details
Published in:Journal of rheumatology 2005-11, Vol.32 (11), p.2186-2188
Main Authors: DE SOUZA, Alexandre W. S, FERNANDES, Vander, FERRARI, Antonio J. L
Format: Article
Language:English
Subjects:
Age of Onset
Aged
Arm
Biological and medical sciences
Cyclosporine - therapeutic use
Diabetes. Impaired glucose tolerance
Diseases of the osteoarticular system
Diuretics - therapeutic use
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Gout - complications
Gout - drug therapy
Gout - physiopathology
Gout Suppressants - therapeutic use
Humans
Immunosuppressive Agents - therapeutic use
Male
Medical sciences
Menopause
Metabolic diseases
Middle Aged
Osteoarthritis - complications
Other metabolic disorders
Premenopause
Purines and pyrimidines (gout, hyperuricemia...)
Sex Characteristics
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Summary:OBJECTIVE: To evaluate and compare clinical and laboratory features of gout in men and women. METHODS: Twenty-seven women and 31 men with gout underwent clinical and laboratory evaluation and review of medical records. RESULTS: Disease onset in women was a mean of 7 years later than in men. There were no differences between women and men regarding systemic hypertension, diabetes mellitus, hyperlipidemia, chronic renal failure, renal stones, ischemic heart disease, or heavy alcohol consumption. Tophaceous gout was similar in both groups, although female gender seemed to be protective against risk of developing tophi (odds ratio: 0.449; 95% confidence interval: 0.151-1.330). Podagra was more common in men, and women showed a higher frequency of upper limb joint involvement. Most patients had low urate excretion rates. Achieving disease control was similar in women and men. Of the 8 women who were premenopausal at disease onset, 7 had secondary causes for gout; 5 of the 8 had high serum urate despite treatment. CONCLUSION: Gout in women had a later onset and higher frequency of upper limb joint involvement in comparison to men. Those with premenopausal onset tended to be refractory to standard therapy.
ISSN:0315-162X
1499-2752