C-Reactive Protein in the Diagnosis, Management, and Prognosis of Neonatal Necrotizing Enterocolitis

In this prospective, observational study, we determined whether serum C-reactive protein (CRP) correlated with necrotizing enterocolitis (NEC) stages II and III. We hypothesized that serial CRP measurement if used as an adjunct to abdominal radiographs would improve the identification of infants wit...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2005-11, Vol.116 (5), p.1064-1069
Main Authors: Pourcyrous, Massroor, Korones, Sheldon B, Yang, Wenjian, Boulden, Thomas F, Bada, Henrietta S
Format: Article
Language:English
Subjects:
Babies
Biological and medical sciences
Biomarkers - blood
C-reactive protein
C-Reactive Protein - analysis
Diagnosis
Disease management
Enterocolitis, Necrotizing - blood
Enterocolitis, Necrotizing - diagnosis
Enterocolitis, Necrotizing - therapy
Enterocolitis, Neonatal necrotizing
Enterocolitis, Pseudomembranous
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal diseases
General aspects
Health aspects
Humans
Infant
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - blood
Infant, Premature, Diseases - diagnosis
Infant, Premature, Diseases - therapy
Infants (Premature)
Medical diagnosis
Medical sciences
Necrotizing enterocolitis
Other diseases. Semiology
Pediatrics
Premature birth
Premature infants
Proteins
Radiography, Abdominal
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Summary:In this prospective, observational study, we determined whether serum C-reactive protein (CRP) correlated with necrotizing enterocolitis (NEC) stages II and III. We hypothesized that serial CRP measurement if used as an adjunct to abdominal radiographs would improve the identification of infants with NEC. Serum CRP level was measured every 12 hours for 3 measurements and, when abnormal, once daily. When clinical signs persisted and the initial abdominal radiographs were abnormal, follow-up radiographs were obtained. Of 241 infants who were evaluated for gastrointestinal signs, 11 had ileus or benign pneumatosis intestinalis with persistently normal CRP; gastrointestinal manifestations resolved within 48 hours, antibiotics were discontinued in
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2004-1806