Cancer therapeutics: Targeting the dark side of Myc

The potent Myc oncoprotein plays a pivotal role as a regulator of tumorigenesis in numerous human cancers of diverse origin. Experimental evidence shows that inhibiting Myc significantly halts tumour cell growth and proliferation. This review summarises recent progress in understanding the function...

Full description

Saved in:
Bibliographic Details
Published in:European journal of cancer (1990) 2005-11, Vol.41 (16), p.2485-2501
Main Authors: Ponzielli, Romina, Katz, Sigal, Barsyte-Lovejoy, Dalia, Penn, Linda Z.
Format: Article
Language:English
Subjects:
Antisense oligonucleotides
Basic-Leucine Zipper Transcription Factors - genetics
Basic-Leucine Zipper Transcription Factors - physiology
Cancer
ChIP-chip
Deregulation
Gene Expression
Genes, myc
Genetic Therapy - methods
Humans
Max
Myc
Neoplasms - genetics
Neoplasms - therapy
Protein-protein interactors
Proto-Oncogene Proteins c-myc - antagonists & inhibitors
Proto-Oncogene Proteins c-myc - genetics
Proto-Oncogene Proteins c-myc - physiology
RNA Interference - physiology
siRNA
Target genes
Therapeutics
Transcription, Genetic - genetics
Transformation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The potent Myc oncoprotein plays a pivotal role as a regulator of tumorigenesis in numerous human cancers of diverse origin. Experimental evidence shows that inhibiting Myc significantly halts tumour cell growth and proliferation. This review summarises recent progress in understanding the function of Myc as a transcription factor, with emphasis on key protein interactions and target gene regulation. In addition, major advances in drug development aimed at eliminating Myc are described, including antisense and triple helix forming oligonucleotides, porphyrins and siRNA. Future anti-Myc strategies are also discussed that inhibit Myc at the level of expression and/or function. Targeting the dark side of Myc with novel therapeutic agents promises to have a profound impact in combating cancer.
ISSN:0959-8049
1879-0852
DOI:10.1016/j.ejca.2005.08.017