Comparison of simple tests for the non‐invasive diagnosis of clinically silent cirrhosis in chronic hepatitis C

• Published in: Alimentary pharmacology & therapeutics 2006-09, Vol.24 (5), p.797-804
• Main Authors: BORRONI, G., CERIANI, R., CAZZANIGA, M., TOMMASINI, M., RONCALLI, M., MALTEMPO, C., FELLINE, C., SALERNO, F.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Alanine Transaminase - blood; Aspartate Aminotransferases - blood; Bilirubin - blood; Biological and medical sciences; Diagnostic Tests, Routine - methods; Digestive system; Female; gamma-Glutamyltransferase - blood; Gastroenterology. Liver. Pancreas. Abdomen; Hepatitis C virus; Hepatitis C, Chronic - blood; Hepatitis C, Chronic - complications; Human viral diseases; Humans; Infectious diseases; Liver Cirrhosis - blood; Liver Cirrhosis - diagnosis; Liver Cirrhosis - virology; Liver Function Tests; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Middle Aged; Other diseases. Semiology; Pharmacology. Drug treatments; Platelet Count; Predictive Value of Tests; Prothrombin Time; Retrospective Studies; Sensitivity and Specificity; Viral diseases; Viral hepatitis
• ISSN: 0269-2813; 1365-2036
• DOI: 10.1111/j.1365-2036.2006.03034.x

Summary Background Biopsy is the gold standard for assessing cirrhosis in patients with chronic hepatitis C virus infection, but it is expensive and at risk of complications. Alternative non‐invasive methods have been developed but their usefulness remains uncertain. Aim To compare the accuracy of five non‐invasive scores in detecting cirrhosis. Methods We reviewed the charts and liver biopsies of 228 consecutive, treatment‐naïve, hepatitis C virus‐positive patients, 13.2% of whom with histological diagnosis of cirrhosis. The five alternative scores were age‐platelet index, cirrhosis discriminant score, aspartate transaminases to platelet ratio index, Pohl's index, and aspartate transaminases/alanine transaminases ratio. Results The specificities of the scores were good (87–100%), but not so their sensitivities (17–67%). Accordingly positive likelihood ratios were generally good but negative likelihood ratios were suboptimal. Combinations of the scores independently related to cirrhosis only slightly change this diagnostic accuracy. Using double cut‐offs to exclude/diagnoses cirrhosis, cirrhosis discriminant score classified 21% of patients without misdiagnoses and aspartate transaminases to platelet ratio index classified 85% of case with 9% of misdiagnoses. Conclusions The five scores showed variable sensitivities and specificities in detecting liver cirrhosis, both individually and in combination. The use of double cut‐off points may make the cirrhosis discriminant score and aspartate transaminases to platelet ratio index useful to reduce the number of patients submitted to liver biopsy.