Diminazene Aceturate Resistance on the Virulence of Trypanosoma brucei for Rats

Four groups (A, B, C and D) of 10 naïve rats were used to compare the virulence of isolates of a strain of Trypanosoma brucei before and after the development of diminazene aceturate resistance. Group A rats were uninfected (controls). Group B rats were infected with a trypanosome isolate unexposed...

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Bibliographic Details
Published in:Journal of comparative pathology 2005-11, Vol.133 (4), p.286-288
Main Authors: Egbe-Nwiyi, T.N., Igbokwe, I.O., Onyeyili, P.A.
Format: Article
Language:English
Subjects:
Animals
Diminazene - analogs & derivatives
Diminazene - pharmacology
diminazene aceturate
disease severity
Drug Resistance
Female
Male
parasitemia
parasitic infection
Rats
strain differences
Trypanocidal Agents - pharmacology
Trypanocidal Agents - therapeutic use
Trypanosoma brucei
Trypanosoma brucei brucei - drug effects
Trypanosoma brucei brucei - isolation & purification
Trypanosoma brucei brucei - pathogenicity
trypanosomiasis
Trypanosomiasis - drug therapy
Trypanosomiasis - prevention & control
Trypanosomiasis - veterinary
Virulence - drug effects
virulence of trypanosomes
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Summary:Four groups (A, B, C and D) of 10 naïve rats were used to compare the virulence of isolates of a strain of Trypanosoma brucei before and after the development of diminazene aceturate resistance. Group A rats were uninfected (controls). Group B rats were infected with a trypanosome isolate unexposed to the drug, while groups C and D rats were infected with two different drug-resistant isolates of the same strain. Rats in the three infected groups each received 10 6 trypanosomes intraperitoneally. Prepatent periods were longer ( P
ISSN:0021-9975
1532-3129
DOI:10.1016/j.jcpa.2005.05.002