Oligonucleotides as antivirals: Dream or realistic perspective?

Many reports have been published on antiviral activity of synthetic oligonucleotides, targeted to act either by a true antisense effect or via non-sequence specific interactions. This short review will try to evaluate the current status of the field by focusing on the effects as reported for inhibit...

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Bibliographic Details
Published in:Antiviral research 2006-09, Vol.71 (2), p.307-316
Main Author: Van Aerschot, Arthur
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antisense oligonucleotides
Antiviral activity
Antiviral agents
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
Biological and medical sciences
Cytomegalovirus - drug effects
HCMV
Herpes simplex virus 1
HIV-1
HIV-1 - drug effects
HSV-1
Human cytomegalovirus
Human immunodeficiency virus 1
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Medical sciences
Oligonucleotides, Antisense - pharmacology
Oligonucleotides, Antisense - therapeutic use
Pharmacology. Drug treatments
Simplexvirus - drug effects
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Virus Diseases - drug therapy
Virus Diseases - virology
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Summary:Many reports have been published on antiviral activity of synthetic oligonucleotides, targeted to act either by a true antisense effect or via non-sequence specific interactions. This short review will try to evaluate the current status of the field by focusing on the effects as reported for inhibition of either HSV-1, HCMV or HIV-1. Following an introduction with a historical background and a brief discussion on the different types of constructs and mechanisms of action, the therapeutic potential of antisense oligonucleotides as antivirals, as well as possible pitfalls upon their evaluation will be discussed.
ISSN:0166-3542
1872-9096
DOI:10.1016/j.antiviral.2006.03.003