Childhood central nervous system tumours – incidence and survival in Europe (1978–1997): Report from Automated Childhood Cancer Information System project

This paper describes the incidence and survival of childhood central nervous system (CNS) tumours in Europe for the period 1978–1997. A total of 19,531 cases, aged 0–14 years, from the ACCIS database were analysed by five regions: the British Isles, East, North, South, and West. Overall age-standard...

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Bibliographic Details
Published in:European journal of cancer (1990) 2006-09, Vol.42 (13), p.2064-2080
Main Authors: Peris-Bonet, Rafael, Martínez-García, Carmen, Lacour, Brigitte, Petrovich, Svetlana, Giner-Ripoll, Begoña, Navajas, Aurora, Steliarova-Foucher, Eva
Format: Article
Language:English
Subjects:
Adolescent
Central Nervous System Neoplasms - epidemiology
Central Nervous System Neoplasms - mortality
Central nervous system tumours
Child
Child, Preschool
Childhood cancer
Databases, Factual - statistics & numerical data
Europe
Europe - epidemiology
Female
Humans
Incidence
Infant
Infant, Newborn
Male
Population-based cancer registries
Registries - statistics & numerical data
Survival
Survival Analysis
Trends
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Summary:This paper describes the incidence and survival of childhood central nervous system (CNS) tumours in Europe for the period 1978–1997. A total of 19,531 cases, aged 0–14 years, from the ACCIS database were analysed by five regions: the British Isles, East, North, South, and West. Overall age-standardised incidence rate (ASR) of CNS tumours in Europe (1988–1997) was 29.9 per million, with the highest rates in the North. Astrocytoma (ASR = 11.8), primitive neuroectodermal tumours (PNET) (ASR = 6.5) and ependymoma (ASR = 3.4) were the most frequent types. Incidence increased significantly during 1978–1997, on average by 1.7% per year. Diagnostic methods may partially explain incidence rates and trends, although a role of variations in risk factors cannot be excluded. Overall 5-year survival was 64% and varied between 72% in the North and 53% in the East. PNET had the poorest prognosis (49%) and astrocytoma the best (75%). Survival has improved by 29% since late 1970s. The positive trends were seen in all regions, although the interregional differences persisted, as a reflection of the different healthcare systems.
ISSN:0959-8049
1879-0852
DOI:10.1016/j.ejca.2006.05.009