HMG-CoA Reductase Inhibitors Do Not Improve Glucose Intolerance in Spontaneously Diabetic Goto–Kakizaki Rats

We examined whether 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) improve glucose intolerance in spontaneously diabetic Goto–Kakizaki (GK) rats or not. The fasting blood glucose, plasma insulin, and serum cholesterol levels were significantly higher in GK rats than t...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2005, Vol.28(11), pp.2092-2095
Main Authors: Satoh, Kumi, Keimatsu, Natsue, Kanda, Makoto, Kasai, Toshinori, Takaguri, Akira, Sun, Fan, Ichihara, Kazuo
Format: Article
Language:English
Subjects:
Animals
Atorvastatin
Blood Glucose - metabolism
Body Weight - drug effects
Cholesterol - blood
diabetes
Diabetes Mellitus - genetics
Glucose Intolerance - drug therapy
Glucose Tolerance Test
Goto–Kakizaki (GK) rat
Heptanoic Acids - therapeutic use
HMG-CoA reductase inhibitor
Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology
insulin
Insulin - blood
Insulin Resistance - physiology
Male
oral glucose tolerance test (OGTT)
Pravastatin - therapeutic use
Pyrroles - therapeutic use
Rats
Rats, Wistar
Simvastatin - therapeutic use
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Summary:We examined whether 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) improve glucose intolerance in spontaneously diabetic Goto–Kakizaki (GK) rats or not. The fasting blood glucose, plasma insulin, and serum cholesterol levels were significantly higher in GK rats than those in age-matched Wistar rats. All rats were given orally once a day 0.5% carboxymethylcellulose, pravastatin 8 mg/kg, simvastatin 8 mg/kg, or atorvastatin 8 mg/kg. An oral glucose tolerance test (OGTT) was performed before and 3, 6 and 12 weeks after statin treatments. The hyperglycemic response to OGTT in GK rats significantly exceeded that in Wistar rats. The plasma insulin level in GK rats increased with age until 14-week-old (treated for 6 weeks), and then decreased. Glucose intake significantly increased the plasma insulin in almost all rats. The increment of plasma insulin due to OGTT in GK rats appeared to be less than that in Wistar rats, because the basal level was already high in GK rats. Pravastatin, simvastatin, and atorvastatin did not modify changes in blood glucose and plasma insulin induced by glucose intake. In conclusion, long-term treatments of GK rats with statins did not improve glucose intolerance observed during OGTT.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.28.2092