Collecting duct carcinoma of kidney producing alpha-fetoprotein

A case of a collecting duct carcinoma (CDC) of the kidney alpha-fetoprotein producing is reported. Serum elevation of alpha-fetoprotein (AFP) is a common marker for hepatocellular carcinoma, although some extrahepatic carcinomas, also of the kidney, with elevated AFP levels have also been reported i...

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Bibliographic Details
Published in:European journal of surgical oncology 2005-11, Vol.31 (9), p.1039-1041
Main Authors: Blandamura, S., Vendraminelli, R., Aversa, S., Fedrigo, M.
Format: Article
Language:English
Subjects:
AFP
alpha-Fetoproteins - biosynthesis
Carcinoma, Renal Cell - metabolism
Carcinoma, Renal Cell - pathology
Collecting duct carcinoma
Humans
Kidney Neoplasms - metabolism
Kidney Neoplasms - pathology
Kidney Tubules, Collecting - pathology
Male
Middle Aged
Therapy
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Summary:A case of a collecting duct carcinoma (CDC) of the kidney alpha-fetoprotein producing is reported. Serum elevation of alpha-fetoprotein (AFP) is a common marker for hepatocellular carcinoma, although some extrahepatic carcinomas, also of the kidney, with elevated AFP levels have also been reported in the literature. A 62-year-old man with a collecting duct carcinoma of the kidney presenting as a mediastinal mass and supra-clavicular lymph node enlargement, and with a serum alpha-fetoprotein (AFP) level of 102.8 μg/L. CDC of the kidney is associated with an aggressive course and extremely poor prognosis. There are no standard treatment regimens, and neither immunotherapy nor chemotherapy has been found to be effective. In the present case, nephrectomy followed by a chemotherapeutic association of carboplatin and gemcitabine gave promising results, with lessening of the patient's symptoms.
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2005.07.001