Map Plasticity in Somatosensory Cortex

Sensory maps in neocortex are adaptively altered to reflect recent experience and learning. In somatosensory cortex, distinct patterns of sensory use or disuse elicit multiple, functionally distinct forms of map plasticity. Diverse approaches--genetics, synaptic and in vivo physiology, optical imagi...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2005-11, Vol.310 (5749), p.810-815
Main Authors: Feldman, Daniel E, Brecht, Michael
Format: Article
Language:English
Subjects:
Analysis
Animals
Axons - physiology
Behavioral neuroscience
Brain
Brain Mapping
Cytology
Dendrites - physiology
Feedback (Response)
Humans
Imaging
Long term depression
Long term potentiation
Mind and body
Models, Neurological
Neonates
Neural Pathways - physiology
Neurology
Neuronal Plasticity
Neurons
Neurons - physiology
Neuroscience
Physiology
Plasticity
rev genes
Reviews
Sensory Experience
Somatosensory Cortex - growth & development
Somatosensory Cortex - physiology
Synapses
Synapses - physiology
Vibrissae - innervation
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Summary:Sensory maps in neocortex are adaptively altered to reflect recent experience and learning. In somatosensory cortex, distinct patterns of sensory use or disuse elicit multiple, functionally distinct forms of map plasticity. Diverse approaches--genetics, synaptic and in vivo physiology, optical imaging, and ultrastructural analysis--suggest a distributed model in which plasticity occurs at multiple sites in the cortical circuit with multiple cellular/synaptic mechanisms and multiple likely learning rules for plasticity. This view contrasts with the classical model in which the map plasticity reflects a single Hebbian process acting at a small set of cortical synapses.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1115807