Prevalence, incidence, and residual risk of human immunodeficiency virus among community and replacement first-time blood donors in São Paulo, Brazil

BACKGROUND:  Concerted efforts have been directed toward recruitment of community rather than replacement donors in Brazil. Time trends and demographic correlates of human immunodeficiency (HIV) prevalence and incidence among first‐time (FT) donors in Brazil were examined by donation type. HIV resid...

Full description

Saved in:
Bibliographic Details
Published in:Transfusion (Philadelphia, Pa.) Pa.), 2005-11, Vol.45 (11), p.1709-1714
Main Authors: Barreto, Claudia C., Sabino, Ester C., Gonçalez, Thelma T., Laycock, Megan E., Pappalardo, Brandee L., Salles, Nanci A., Wright, David J., Chamone, Dalton F., Busch, Michael P.
Format: Article
Language:English
Subjects:
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood and lymphatic vessels
Blood Donors - statistics & numerical data
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Brazil - epidemiology
Cardiology. Vascular system
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
HIV Infections - epidemiology
HIV Infections - transmission
Human viral diseases
Humans
Incidence
Infectious diseases
Male
Medical sciences
Middle Aged
Miscellaneous
Prevalence
Residence Characteristics
Risk Assessment
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Viral diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND:  Concerted efforts have been directed toward recruitment of community rather than replacement donors in Brazil. Time trends and demographic correlates of human immunodeficiency (HIV) prevalence and incidence among first‐time (FT) donors in Brazil were examined by donation type. HIV residual risk from FT‐donor transfusions, and projected yield of p24 antigen and nucleic acid test (NAT) screening were estimated. STUDY DESIGN AND METHODS:  HIV prevalence data and seroreactive specimens were obtained at Fundação Pró‐Sangue/Hemocentro‐de‐São Paulo from 1995 to 2001. To estimate incidence, confirmed‐positive samples from July 1998 through December 2001 were tested with a less‐sensitive (detuned) enzyme immunoassay to detect recent seroconversions. Incidence data were used to estimate residual risk and p24 and NAT yield based on published window periods (WPs). RESULTS:  HIV prevalence was 22 percent higher among the FT community donors than replacement donors (19.6 vs. 16.1 per 10,000; p 
ISSN:0041-1132
1537-2995
DOI:10.1111/j.1537-2995.2005.00575.x