Aminoarenethiolate−Copper(I)-Catalyzed Amination of Aryl Bromides

Aminoarenethiolate−copper(I) complexes are known to be efficient catalysts for carbon−carbon bond formation. Here, we show the first examples that these thiolate−copper(I) complexes are efficient for carbon−nitrogen bond formation reactions as well. N-Arylation of benzylamine and imidazole with brom...

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Bibliographic Details
Published in:Organic letters 2005-11, Vol.7 (23), p.5241-5244
Main Authors: Jerphagnon, Thomas, van Klink, Gerard P. M, de Vries, Johannes G, van Koten, Gerard
Format: Article
Language:English
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Summary:Aminoarenethiolate−copper(I) complexes are known to be efficient catalysts for carbon−carbon bond formation. Here, we show the first examples that these thiolate−copper(I) complexes are efficient for carbon−nitrogen bond formation reactions as well. N-Arylation of benzylamine and imidazole with bromobenzene was achieved either in NMP as solvent or under solvent-free conditions in the presence of 2.5 mol % of aminoarenethiolate−copper(I) complex only.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol052113z