Depression and anxiety in patients with hepatitis C: prevalence, detection rates and risk factors

We examined a group of patients awaiting interferon treatment for hepatitis C to estimate the prevalence and detection rates of and risk factors for mood disorders. The Structured Clinical Interview for DSM-IV Axis I Disorders: Clinician Version was used to detect psychiatric disorder. Self-completi...

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Bibliographic Details
Published in:General hospital psychiatry 2005-11, Vol.27 (6), p.431-438
Main Authors: Golden, Jeannette, O'Dwyer, Anne Marie, Conroy, Ronán M.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Anxiety
Anxiety - epidemiology
Anxiety - etiology
Biological and medical sciences
Depression
Depression - epidemiology
Depression - etiology
Detection
Female
Hepatitis C
Hepatitis C - complications
Hepatitis C - psychology
Human viral diseases
Humans
Infectious diseases
Ireland - epidemiology
Male
Medical sciences
Middle Aged
Mood disorders
Prevalence
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Risk Factors
Viral diseases
Viral hepatitis
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Summary:We examined a group of patients awaiting interferon treatment for hepatitis C to estimate the prevalence and detection rates of and risk factors for mood disorders. The Structured Clinical Interview for DSM-IV Axis I Disorders: Clinician Version was used to detect psychiatric disorder. Self-completion instruments were used to rate symptom severity, subjective cognitive function, work and social adjustment, stigma, acceptance of illness and treatment satisfaction. The 90 participants included 23 women (26%); 33 (37%) had contracted hepatitis C iatrogenically, 42 (47%) through injecting drug use and the remainder (17%) were of unknown origin. There was a 28% 1-month prevalence of depressive disorders, 72% of whom were previously undiagnosed, and a 24% prevalence of anxiety disorders, 86% previously undiagnosed. Current methadone maintenance was strongly associated with risk of depression (odds ratio, 5.0; 95% CI, 1.08–23.0). After adjustment for age and sex, depression was associated with poorer work and social adjustment, lower acceptance of illness, higher illness stigma, poorer reported thinking and concentration, and higher levels of subjective physical symptoms (all P
ISSN:0163-8343
1873-7714
DOI:10.1016/j.genhosppsych.2005.06.006