Tungtungmadic acid, a novel antioxidant, from Salicornia herbacea

Tungtungmadic acid (3-caffeoyl-4-dihydrocaffeoyl quinic acid) is a new chlorogenic acid derivative that was isolated from the Salicornia herbacea. The structure of tungtungmadic acid was determined using chemical and spectral analysis. The antioxidant activity of tungtungmadic acid was evaluated usi...

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Bibliographic Details
Published in:Archives of pharmacal research 2005-10, Vol.28 (10), p.1122-1126
Main Authors: Chung, Young Chul, Chun, Hyo Kon, Yang, Jae Young, Kim, Ji Young, Han, Eun Hee, Kho, Yung Hee, Jeong, Hye Gwang
Format: Article
Language:English
Subjects:
Amaranthaceae - chemistry
Animals
Antioxidants - chemistry
Antioxidants - isolation & purification
Antioxidants - pharmacology
Chlorogenic Acid - chemistry
Chlorogenic Acid - isolation & purification
Chlorogenic Acid - pharmacology
DNA Damage - drug effects
Dose-Response Relationship, Drug
Lipid Peroxidation - drug effects
Male
Mice
Mice, Inbred ICR
Microsomes, Liver - drug effects
Microsomes, Liver - metabolism
Molecular Structure
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
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Summary:Tungtungmadic acid (3-caffeoyl-4-dihydrocaffeoyl quinic acid) is a new chlorogenic acid derivative that was isolated from the Salicornia herbacea. The structure of tungtungmadic acid was determined using chemical and spectral analysis. The antioxidant activity of tungtungmadic acid was evaluated using various antioxidant assays, including free radical scavenging, lipid peroxidation and hydroxyl radical-induced DNA strand breaks assays. Tungtungmadic acid (IC50 = 5.1 microM and 9.3 microM) was found to have higher antioxidant activity in the DPPH scavenging assay as well as in the iron-induced liver microsomal lipid peroxidation system. In addition, the tungtungmadic acid was also effective in protecting the plasmid DNA against strand breakage induced by hydroxyl radicals.
ISSN:0253-6269
DOI:10.1007/bf02972972