A Review of Microvascular Measurements in Wound Healing

The microcirculatory evaluation in patients affected by arteriopathic or venous ulcers is usually carried out using laser Doppler flowmetry, transcutaneous oxygen (transcutaneous pressure of oxygen, TcPO2), and carbon dioxide (transcutaneous pressure of carbon dioxide, TcPCO2) measurements and capil...

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Bibliographic Details
Published in:International journal of lower extremity wounds 2006-09, Vol.5 (3), p.181-199
Main Authors: Iabichella, M. L., Melillo, E., Mosti, G.
Format: Article
Language:English
Subjects:
Blood Gas Monitoring, Transcutaneous - instrumentation
Care and treatment
Equipment Design
Humans
Laser Doppler blood flowmetry
Laser-Doppler Flowmetry - instrumentation
Leg
Leg Ulcer - blood
Leg Ulcer - pathology
Leg Ulcer - physiopathology
Microcirculation - physiology
Microscopic Angioscopy - instrumentation
Reproducibility of Results
Skin - blood supply
Ulcers
Varicose ulcer
Wound Healing - physiology
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Summary:The microcirculatory evaluation in patients affected by arteriopathic or venous ulcers is usually carried out using laser Doppler flowmetry, transcutaneous oxygen (transcutaneous pressure of oxygen, TcPO2), and carbon dioxide (transcutaneous pressure of carbon dioxide, TcPCO2) measurements and capillaroscopy. These techniques provide significant pathophysiologic and prognostic information. TcPO2 and TcPCO2 diagnose and classify the extent of arterial disease in the leg ulcers caused by arterial disease; the prognostic value is recognized, though doubts about its prognostic potential exist in the case of leg ulcer. Laser Doppler flowmetry is able to identify the first functional impairment in the early stages of the arterial disease and in the complicated venous insufficiency. Capillaroscopy gives us morphological and quantitative parameters of the capillary bed that is damaged in arteriopathic and venous ulcers; nevertheless, it does not provide us with definite prognostic indexes. Combining the 3 methods may contribute to yield objective measures in the clinical management of lower extremity ulcers.
ISSN:1534-7346
1552-6941
DOI:10.1177/1534734606292492