The Inflammasome: First Line of the Immune Response to Cell Stress

The NALP3-inflammasome is a protein complex that stimulates caspase-1 activation to promote the processing and secretion of proinflammatory cytokines. Recent work indicates that the NALP3-inflammasome can be activated by endogenous “danger signals” as well as compounds associated with pathogens ( Ka...

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Bibliographic Details
Published in:Cell 2006-08, Vol.126 (4), p.659-662
Main Authors: Ogura, Yasunori, Sutterwala, Fayyaz S., Flavell, Richard A.
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Animals
Apoptosis Regulatory Proteins - genetics
Apoptosis Regulatory Proteins - metabolism
Calcium Pyrophosphate - metabolism
Calcium-Binding Proteins - genetics
Calcium-Binding Proteins - metabolism
CARD Signaling Adaptor Proteins
Carrier Proteins - genetics
Carrier Proteins - metabolism
Caspase 1 - metabolism
Cytoskeletal Proteins - genetics
Cytoskeletal Proteins - metabolism
Enzyme Activation
Humans
Immune System - physiology
Inflammation - metabolism
Interleukins - immunology
NLR Family, Pyrin Domain-Containing 3 Protein
Oxidative Stress
Salmonella Infections - immunology
Salmonella typhimurium - immunology
Uric Acid - metabolism
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Summary:The NALP3-inflammasome is a protein complex that stimulates caspase-1 activation to promote the processing and secretion of proinflammatory cytokines. Recent work indicates that the NALP3-inflammasome can be activated by endogenous “danger signals” as well as compounds associated with pathogens ( Kanneganti et al., 2006; Mariathasan et al., 2006; Martinon et al., 2006; Sutterwala et al., 2006). Here, we discuss new insights into the regulation of caspase-1 activity in the inflammatory response.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2006.08.002