The p53 tumor suppressor participates in multiple cell cycle checkpoints

The process of cell division is highly ordered and regulated. Checkpoints exist to delay progression into the next cell cycle phase only when the previous step is fully completed. The ultimate goal is to guarantee that the two daughter cells inherit a complete and faithful copy of the genome. Checkp...

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Bibliographic Details
Published in:Journal of cellular physiology 2006-10, Vol.209 (1), p.13-20
Main Authors: Giono, Luciana E., Manfredi, James J.
Format: Article
Language:English
Subjects:
Animals
Cell Cycle
DNA Repair
G1 Phase
G2 Phase
Genes, cdc
Humans
Mice
Models, Biological
S Phase
Signal Transduction
Spindle Apparatus - genetics
Tumor Suppressor Protein p53 - physiology
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Summary:The process of cell division is highly ordered and regulated. Checkpoints exist to delay progression into the next cell cycle phase only when the previous step is fully completed. The ultimate goal is to guarantee that the two daughter cells inherit a complete and faithful copy of the genome. Checkpoints can become activated due to DNA damage, exogenous stress signals, defects during the replication of DNA, or failure of chromosomes to attach to the mitotic spindle. Abrogation of cell cycle checkpoints can result in death for a unicellular organism or uncontrolled proliferation and tumorigenesis in metazoans (Nyberg et al., 2002). The tumor suppressor p53 plays a critical role in each of these cell cycle checkpoints and is reviewed here. J. Cell. Physiol. 209: 13–20, 2006. © 2006 Wiley‐Liss, Inc.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.20689