Outcome in neonates with congenital heart disease referred for respiratory extracorporeal membrane oxygenation

Aim: To evaluate the proportion of neonates referred for extracorporeal membrane oxygenation (ECMO) support in the modern era of advanced conventional treatments for respiratory failure who actually had congenital heart disease (CHD), and to assess the impact of this diagnostic route on patient cond...

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Bibliographic Details
Published in:Acta Paediatrica 2005-09, Vol.94 (9), p.1280-1284
Main Authors: Brown, Kate L., Miles, Fiona, Sullivan, Ian D., Hoskote, Aparna, Verhulst, Linda, Ridout, Deborah A., Goldman, Allan P.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiac surgery
congenital heart disease
Critical Care
Extracorporeal Membrane Oxygenation
Female
General aspects
Heart Defects, Congenital - complications
Humans
Infant, Newborn
Intensive Care Units, Neonatal
Male
Medical sciences
neonatal intensive care
Respiratory Insufficiency - etiology
Respiratory Insufficiency - therapy
Retrospective Studies
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
Treatment Outcome
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Summary:Aim: To evaluate the proportion of neonates referred for extracorporeal membrane oxygenation (ECMO) support in the modern era of advanced conventional treatments for respiratory failure who actually had congenital heart disease (CHD), and to assess the impact of this diagnostic route on patient condition and outcome. Methods: A retrospective case‐note review of neonatal ECMO and cardiac admissions to a single, tertiary ECMO and cardiac intensive care unit (ICU) between March 1999 and February 2002. Results: 287 symptomatic neonates presented to the ICU with previously undiagnosed cardiac or respiratory disease. Eighty‐two with presumed respiratory failure were referred for ECMO, and 205 with suspected CHD were referred for cardiac evaluation. Eight (10%) ECMO referrals, all with presumed persistent pulmonary hypertension of the newborn (PPHN), were found to have CHD (transposition: 3; total anomalous pulmonary venous connection: 3; left heart obstructive lesions: 2). Mortality in this group was 50%, compared with 11% for correctly identified CHD patients (odds ratio 8.2, 95% CI 1.92, 35.4, p
ISSN:0803-5253
1651-2227
DOI:10.1111/j.1651-2227.2005.tb02089.x