Improvement of walking disturbance by beraprost sodium in rat femoral artery occlusion models

In rats receiving bilateral femoral arteries ligation (day 0), repeated oral administration of the prostacyclin derivative beraprost sodium (50 μg/kg, b.i.d.) from day 1 to day 5 resulted in a significant prolongation in walking time in rotarod walking exercise performed on day 5. Similarly, results...

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Bibliographic Details
Published in:European journal of pharmacology 2006-09, Vol.545 (2), p.173-176
Main Authors: Miyamoto, Mitsuko, Tayama, Toshikazu, Yamaguchi, Sin'ichi, Kaneko, Masayuki, Kurumatani, Hajimu
Format: Article
Language:English
Subjects:
Animals
Arterial Occlusive Diseases - drug therapy
Beraprost sodium
Biological and medical sciences
Epoprostenol - analogs & derivatives
Epoprostenol - therapeutic use
Femoral Artery
Intermittent claudication
Intermittent Claudication - drug therapy
Male
Medical sciences
Pharmacology. Drug treatments
Rats
Rats, Wistar
Regional Blood Flow - drug effects
Walking
Walking disturbance
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Summary:In rats receiving bilateral femoral arteries ligation (day 0), repeated oral administration of the prostacyclin derivative beraprost sodium (50 μg/kg, b.i.d.) from day 1 to day 5 resulted in a significant prolongation in walking time in rotarod walking exercise performed on day 5. Similarly, results were obtained in rats with bilateral femoral arterial thrombosis induced by application of FeCl 3/HCl. In the ligation model, a significant increase was observed in femoral/carotid arterial blood pressure ratio even on day 2. These results indicated that beraprost sodium improves blood flow and walking disturbances associated with arterial occlusion in rats.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2006.06.050