Comparative study of adult human skin fibroblasts and umbilical fibroblast-like cells

Expression of markers, collagens, and HLA-1 by human skin fibroblasts and fibroblast-like cells isolated from the umbilical Wharton's jelly was compared. Skin fibroblasts express collagens (proteins characteristic of differentiated cells of this histogenetic series) and HLA-1, while umbilical c...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2006-01, Vol.141 (1), p.161-166
Main Authors: Yarygin, K N, Suzdal'tseva, Yu G, Burunova, V V, Voronov, A V, Petrakova, N V, Cheglakov, I B, Stupin, V A, Yarygin, V N
Format: Article
Language:English
Subjects:
AC133 Antigen
Animals
Antigens - analysis
Antigens, CD - analysis
Antigens, CD34 - analysis
Biomarkers - analysis
Collagen Type I - analysis
Collagen Type II - analysis
Female
Fibroblasts - chemistry
Fibroblasts - transplantation
Glycoproteins - analysis
HLA-A1 Antigen - analysis
Humans
Immunohistochemistry
Intermediate Filament Proteins - analysis
Nerve Tissue Proteins - analysis
Nestin
Peptides - analysis
Rats
Rats, Wistar
Skin - cytology
Umbilical Cord - cytology
Vimentin - analysis
von Willebrand Factor - immunology
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Summary:Expression of markers, collagens, and HLA-1 by human skin fibroblasts and fibroblast-like cells isolated from the umbilical Wharton's jelly was compared. Skin fibroblasts express collagens (proteins characteristic of differentiated cells of this histogenetic series) and HLA-1, while umbilical cells express, in addition to collagens, juvenile surface markers and almost no HLA-1. This indicates that fibroblast-like cells isolated from different sources are different and can serve as sources for the creation of cell preparations with different characteristics in future.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-006-0117-0