Genetic variability at the LXR gene ( NR1H2) may contribute to the risk of Alzheimer's disease

We have initiated a systematic analysis of the role of cholesterol metabolizing genes as risk factors for Alzheimer's disease pathogenesis. As part of this analysis, we have assessed the NR1H2 gene on chromosome 19 and report here a modest association with the locus in sibpairs with late onset...

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Bibliographic Details
Published in:Neurobiology of aging 2006-10, Vol.27 (10), p.1431-1434
Main Authors: Adighibe, Omanma, Arepalli, Sampath, Duckworth, Jaime, Hardy, John, Wavrant-De Vrièze, Fabienne
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer Disease - enzymology
Alzheimer Disease - epidemiology
Alzheimer Disease - genetics
Alzheimer's disease
Apolipoproteins E - genetics
Cholesterol
Chromosome Aberrations
Chromosomes, Human, Pair 19 - genetics
DNA Mutational Analysis - methods
Female
Genetic Predisposition to Disease - epidemiology
Genetic Predisposition to Disease - genetics
Genetic Testing - methods
Genetic Variation - genetics
Genetics
Heterozygote
Humans
Incidence
Liver X Receptors
LXR gene
Male
Middle Aged
Orphan Nuclear Receptors
Polymorphism, Genetic
Receptors, Cytoplasmic and Nuclear - genetics
Retrospective Studies
Risk Assessment - methods
Risk Factors
United States - epidemiology
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Summary:We have initiated a systematic analysis of the role of cholesterol metabolizing genes as risk factors for Alzheimer's disease pathogenesis. As part of this analysis, we have assessed the NR1H2 gene on chromosome 19 and report here a modest association with the locus in sibpairs with late onset disease.
ISSN:0197-4580
1558-1497
DOI:10.1016/j.neurobiolaging.2005.08.010