Cerebroprotective effect of a new taurine derivative during cerebral ischemia

A new taurine derivative chlorohydrate-N-isopropylamide-2-(1-phenylethyl)aminoethanesulfonic acid normalized energy metabolism, inhibited lipid peroxidation, and reactivated antioxidant enzymes in the brain of rats exposed to ischemia. This taurine derivative decreased the mortality rate of animals...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2006-01, Vol.141 (1), p.44-47
Main Authors: Sapronov, N S, Bul'on, V V, Krylova, I B, Gavrovskaya, L K, Selina, E N, Evdokimova, N R
Format: Article
Language:English
Subjects:
Animals
Brain Ischemia - drug therapy
Energy Metabolism - drug effects
Lipid Peroxidation - drug effects
Neuroprotective Agents - chemistry
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Rats
Taurine - analogs & derivatives
Taurine - chemistry
Taurine - pharmacology
Taurine - therapeutic use
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Summary:A new taurine derivative chlorohydrate-N-isopropylamide-2-(1-phenylethyl)aminoethanesulfonic acid normalized energy metabolism, inhibited lipid peroxidation, and reactivated antioxidant enzymes in the brain of rats exposed to ischemia. This taurine derivative decreased the mortality rate of animals with ischemic changes in cerebral circulation. The test compound was more potent than piracetam in producing the cerebroprotective effect.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-006-0089-0