Reactions between human serum gamma-globulin and zinc cations

Interactions of human serum gamma-globulin with zinc cations in solution were studied by differential spectrophotometry in UV light. Supraphysiological concentrations of zinc caused an increment in optical density of protein solution reflecting the effect of gamma-globulin saturation with the metal....

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2005-08, Vol.140 (2), p.209-212
Main Authors: Cheknev, S B, Babaeva, E E, Vorobeva, U A, Denisova, E A
Format: Article
Language:English
Subjects:
Cations
Dose-Response Relationship, Drug
gamma-Globulins - chemistry
Humans
Hydrogen-Ion Concentration
Protein Binding
Protein Conformation
Proteins - chemistry
Spectrophotometry
Time Factors
Ultraviolet Rays
Zinc - chemistry
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Summary:Interactions of human serum gamma-globulin with zinc cations in solution were studied by differential spectrophotometry in UV light. Supraphysiological concentrations of zinc caused an increment in optical density of protein solution reflecting the effect of gamma-globulin saturation with the metal. Zinc concentrations below physiological led to hypochromism in the protein absorption spectrum. Conformation changes in gamma-globulin during interactions with zinc are analyzed for the surface and intramolecular binding sites and are compared with the effects of copper cations.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0447-3