Identification of serovar-specific single-nucleotide polymorphisms of C. Trachomatis omp1 gene

Complete sequences of omp1 gene encoding chlamydial main outer membrane protein were analyzed in 76 clinical strains of C. trachomatis. Thirty-four serovar-specific single-nucleotide polymorphisms were identified, 20 of them meet two criteria: unique position of the nucleotide and unique nucleotide...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2005-08, Vol.140 (2), p.222-227
Main Authors: Sharkeev, V I, Torshin, I Y, Shkarupeta, M M, Akopian, T A, Lazarev, V N, Govorun, V M
Format: Article
Language:English
Subjects:
Chlamydia trachomatis - genetics
Genetic Variation
Models, Genetic
Polymorphism, Single Nucleotide
Porins - genetics
Sequence Analysis, DNA
Species Specificity
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Summary:Complete sequences of omp1 gene encoding chlamydial main outer membrane protein were analyzed in 76 clinical strains of C. trachomatis. Thirty-four serovar-specific single-nucleotide polymorphisms were identified, 20 of them meet two criteria: unique position of the nucleotide and unique nucleotide substitution. Evaluation of serovar-specific single-nucleotide polymorphisms of omp1 gene can appreciably simplify and accelerate genetic diagnosis of C. trachomatis serovars.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0451-7