Cytotoxic activity of lymphocytes isolated from mouse liver involved into tumor process

We studied cytotoxic activity and immunophenotype of mononuclear cells isolated from the liver of mice after implantation of ovarian cancer cells into the liver parenchyma. The isolated cells exhibited higher natural killer cell activity and possessed higher cytotoxic potential against autologous tu...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2006-01, Vol.141 (1), p.70-72
Main Authors: Akhmatova, N K, Kuzovlev, E N, Lebedinskaya, O V, Donenko, F V, Shubina, I Zh, Makashin, A I, Kiselevskii, M V
Format: Article
Language:English
Subjects:
Animals
CD3 Complex - analysis
Cytotoxicity, Immunologic
Female
Flow Cytometry
Killer Cells, Natural - immunology
Liver - immunology
Lymphocytes - immunology
Male
Mice
Mice, Inbred CBA
Neoplasm Transplantation
Ovarian Neoplasms - immunology
Spleen - immunology
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Summary:We studied cytotoxic activity and immunophenotype of mononuclear cells isolated from the liver of mice after implantation of ovarian cancer cells into the liver parenchyma. The isolated cells exhibited higher natural killer cell activity and possessed higher cytotoxic potential against autologous tumor cells compared to spleen lymphocytes. The ratio of CD3+ lymphocytes and natural killer cells was high in the liver with tumor metastases. Lymphoid cells were practically absent in the liver of intact animals. Natural killer cells and T cells from liver tumor tissue play an important role in antitumor immunity and can be used for local and regional adjuvant immunotherapy of liver metastases.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-006-0096-1