Effect of weight loss on inflammatory and endothelial markers and FMD using two low-fat diets

OBJECTIVE: Cardiovascular disease is strongly associated with obesity and there is evidence that weight loss has positive effects on cardiovascular disease risk. The aims of this study were to compare meal replacements (MR) with a conventional low-fat diet as weight loss strategies and to examine th...

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Bibliographic Details
Published in:International Journal of Obesity 2005-12, Vol.29 (12), p.1445-1451
Main Authors: Clifton, P M, Keogh, J B, Foster, P R, Noakes, M
Format: Article
Language:English
Subjects:
Adhesion
Adult
Biological and medical sciences
Biomarkers - blood
Blood Flow Velocity - physiology
Blood pressure
Body Mass Index
Brachial Artery - diagnostic imaging
Brachial Artery - physiopathology
Cardiovascular diseases
Cardiovascular Diseases - blood
Cardiovascular Diseases - prevention & control
Diet
Diet, Fat-Restricted
Diet, Reducing - methods
Epidemiology
Female
Health Promotion and Disease Prevention
Health risks
Humans
Insulin
Internal Medicine
Lipids
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Obesity
Obesity - blood
Obesity - diet therapy
Obesity - physiopathology
Public Health
Research methods
Risk Factors
Ultrasonography
Vasodilation - physiology
Wave velocity
Weight Loss - physiology
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Summary:OBJECTIVE: Cardiovascular disease is strongly associated with obesity and there is evidence that weight loss has positive effects on cardiovascular disease risk. The aims of this study were to compare meal replacements (MR) with a conventional low-fat diet as weight loss strategies and to examine the effect of weight loss on flow-mediated dilatation (FMD) and other markers of endothelial function in overweight Australians with raised triglycerides (TG) (>2 mmol/l). RESEARCH METHODS: Subjects matched for age, gender, fasting plasma TG and body mass index were randomized to two low- fat high- carbohydrate weight loss strategies (both
ISSN:0307-0565
1476-5497
DOI:10.1038/sj.ijo.0803039