Effects of dopexamine on the intestinal microvascular blood flow and leukocyte activation in a sepsis model in rats

The administration of dopexamine may constitute a therapeutical option to improve hepatosplanchnic perfusion in sepsis. In order to verify this hypothesis, we administered dopexamine in an experimental sepsis model in rats. This prospective, randomized, controlled laboratory study was conducted in 4...

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Bibliographic Details
Published in:Critical care (London, England) England), 2006, Vol.10 (4), p.R117-R117
Main Authors: Birnbaum, Jurgen, Klotz, Edda, Spies, Claudia D, Lorenz, Bjorn, Stuebs, Patrick, Hein, Ortrud Vargas, Grundling, Matthias, Pavlovic, Dragan, Usichenko, Taras, Wendt, Michael, Kox, Wolfgang J, Lehmann, Christian
Format: Article
Language:English
Subjects:
Animals
Disease Models, Animal
Dopamine - analogs & derivatives
Dopamine - pharmacology
Dopamine - therapeutic use
Intestinal Mucosa - blood supply
Intestinal Mucosa - drug effects
Intestinal Mucosa - metabolism
Intestines - blood supply
Intestines - drug effects
Intestines - metabolism
Leukocytes - drug effects
Leukocytes - metabolism
Male
Microcirculation - drug effects
Microcirculation - metabolism
Rats
Rats, Wistar
Regional Blood Flow - drug effects
Regional Blood Flow - physiology
Sepsis - drug therapy
Sepsis - metabolism
Sepsis - physiopathology
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Summary:The administration of dopexamine may constitute a therapeutical option to improve hepatosplanchnic perfusion in sepsis. In order to verify this hypothesis, we administered dopexamine in an experimental sepsis model in rats. This prospective, randomized, controlled laboratory study was conducted in 42 Wistar rats. The animals were divided into 3 groups. Group 1 (CON group) served as control group. The Animals of groups 2 (LPS Group) and 3 received an endotoxin infusion (20 mg/kgfor 15 min). In addition, in group 3 (DPX group) dopexamine was administered 0.5 microg/kg/minover 4 hours. One half of the animals of each group underwent studies of intestinal microvascular blood flow (IMBF) using laser Doppler fluxmetry. In the other half an intravital microscopic evaluation of the leukocyte endothelium cell interaction in the intestinal microcirculation was performed. Functional capillary denstity (FCD) in the intestinal mucosaand the circular as well as the longitudinal muscle layer was estimated. One hour after endotoxin challenge IMBF decreased significantly in the untreated LPS group to 51% compared to baseline (p
ISSN:1364-8535
1466-609X