Carnosine-induced changes in the development of spermatogenic epithelial cells in senescence accelerated SAM mice

Carnosine significantly increased the number of spermatogonia and Sertoli cells in mice prone (SAMP1) and resistant (SAMR1) to accelerated aging and appreciably reduced cell yield in meiosis and spermiogenesis in SAMP1 mice. In experimental SAMP1 mice catastrophic changes in the number of gametes we...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2005-08, Vol.140 (2), p.235-237
Main Authors: Gopko, A V, Kulibin, A Y, Semenova, M L, Zakhidov, S T
Format: Article
Language:English
Subjects:
Aging
Animals
Carnosine - pharmacology
Cellular Senescence
Epithelial Cells - metabolism
Male
Meiosis
Mice
Sertoli Cells - pathology
Spermatogenesis - drug effects
Spermatozoa - drug effects
Spermatozoa - pathology
Testis - metabolism
Time Factors
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Summary:Carnosine significantly increased the number of spermatogonia and Sertoli cells in mice prone (SAMP1) and resistant (SAMR1) to accelerated aging and appreciably reduced cell yield in meiosis and spermiogenesis in SAMP1 mice. In experimental SAMP1 mice catastrophic changes in the number of gametes were paralleled by intensive degradation of the spermatogenic epithelium. In SAMR1 mice treated with carnosine highly ordered spermatogenic structure was preserved.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0454-4