Association study of seven polymorphisms in four serotonin receptor genes on suicide victims

A number of molecular genetic studies have investigated if serotonin (5‐HT) receptor subtypes are involved in the pathogenesis of depression, suicidal behavior, aggression, and impulsive behavior. Existence of many receptor subtypes for a single transmitter permits a great diversity of signaling rai...

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Bibliographic Details
Published in:American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2006-09, Vol.141B (6), p.669-672
Main Authors: Videtic, Alja, Pungercic, Galina, Pajnic, Irena Zupanic, Zupanc, Tomaz, Balazic, Joze, Tomori, Martina, Komel, Radovan
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Aged
Biological and medical sciences
candidate gene
Case-Control Studies
Female
genetics
Humans
Male
Medical sciences
Middle Aged
Polymorphism, Genetic
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Receptors, Serotonin - genetics
serotonergic system
Slavic/Slovenian ethnicity
Suicide
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Summary:A number of molecular genetic studies have investigated if serotonin (5‐HT) receptor subtypes are involved in the pathogenesis of depression, suicidal behavior, aggression, and impulsive behavior. Existence of many receptor subtypes for a single transmitter permits a great diversity of signaling raising the possibility that they may serve as genetic markers for suicidal behavior. Most previous studies of suicide have analyzed polymorphisms of the receptors 5‐HT1A, 5‐HT1B, 5‐HT2A, fewer have examined 5‐HT1F. We report a study of possible association between the polymorphisms in the 5‐HT receptor genes (1A, 1B, 1F, and 2A) and suicidal behavior on a sample of 226 suicide victims and 225 healthy control subjects. No significant differences in genotype frequency distributions between the suicide victims and healthy control subjects were observed for four polymorphisms; three were not polymorphic. A single polymorphism, C‐1420T in gene 5‐HT2A, showed a slight association with suicide (χ2 = 4.94, df = 2, P = 0.067), but the correlation was not statistically significant. None of the tested genetic variants of serotonin receptors appears to be associated with suicidal behavior in the Slovenian population which has a relatively high suicide rate. © 2006 Wiley‐Liss, Inc.
ISSN:1552-4841
1552-485X
DOI:10.1002/ajmg.b.30390